Isyaku et al. JOBASFUD_2025_4_2_010
Keywords: Adansonia digitata l., Indomethacin-induced gastric ulceration, Wistar Rats.
2026-01-31 DOI: JOBASFUD_2025_4_2_010
Background: Peptic ulcer disease (PUD) poses a significant health risk which occurs due to an imbalance between some endogenous aggressive factors and defensive factors. The study aims to explore the potential effects of Adansonia digitate l. (A. digitata l.) leaves aqueous extract against indomethacin (IND) induced gastric mucosal damage in Wistar rats. Methods: The research was an experimental study design. A total of 30 Wistar rats were randomly distributed into six groups of five Wistar rats each. Group 1(control) receive distilled water only, Group 2 (IND) group receive 50mg/kg of indomethacin (IND), Group 3 (CMD) group receive 100mg/kg cimetidine (CMD) for 14 days before ulcer induction, Group 4, 5 and 6 receive 100mg/kg, 150mg/kg and 200mg/kg aqueous extract A. digitata l. (A.D) for 14 days before IND administration respectively. IND (50mg/kg) was administered intraperitoneally to each group after 48h of fasting using raised wire mesh cage to induce gastric ulceration. The gastric tissues harvested were used for histological studies. Data were analyzed using IBM SPSS version 22. Results: Pre-treatment with cimetidine and aqueous extract at 150mg/kg AD+IND and 200mg/kg AD+IND significantly decreases (P<0.05) the ulcer score and ulcer index compared to IND group. Percentage inhibition of ulcer increases (36.2%, 49.9% and 57.7%) in extract treatment groups compared to percentage inhibition of ulcer in IND (29.0%) group. Histological studies of gastric tissues show damaged and denuded mucosa in the indomethacin group which were reversed by the protective effects of aqueous extract. Conclusion: The extract provides the protective effects against the damaging effects of indomethacin shown in the histological studies and gastric ulcer parameters.