EFFECT OF CAFFEINE ON STRESS-INDUCED HYPERGLYCAEMIA IN FEMALE WISTAR RATS
Musa et al. J Biomed & App Sci FUD (2024) 3:2
Keywords: Caffeine, stress, hyperglycaemia, underwater, predator
2025-05-16 DOI: JOBASFUD_2024_3_2_002
Abstract
Background: Caffeine is a commonly used psycho-active agent present in cocoa, coffee, tea and a lot of beverages. It is believed to ameliorate depression and anxiety due to its ability to antagonize the adenosine receptors in the CNS. The aim of this study is to find out the effect of caffeine on stress-induced hyperglycemia using underwater trauma and predator model of stress in female Wistar rats. Methods: The rats were first exposed to a cat for 30 minutes, followed by 20 seconds forced swimming in a plastic water container. After the forced swimming, the rats were submerged in water for another 10 seconds followed by a single dose of caffeine given intraperitoneally at dosage of 10, 20 & 40 mg/kg respectively. A week later, the serum glucose level of the rats was assayed using a glucometer. Results: Stress was found to significantly increase the serum glucose level of the rats with significantly reduction in the elevated blood glucose level in the caffeine treated group compared to the rats in the control group. Conclusion: Caffeine reduces stress-induced in female Wistar rats.