El-ta’alu & Ahmad, J Biomed & App Sci FUD (2024) 3:1
Keywords: Psoriasis, collagen, connective tissue, finoptine
2024-06-28 DOI: JOBASFUD_2024_3_1_003
Background of the Study: Pathogenesis of psoriasis involves disorders in Connective Tissue Metabolism (CTM) - that of collagen, elastin and glycosaminoglycan structural macromolecules. The disorder influences the production, concentration, and urinary excretion of hydroxyproline byproduct. Changes occurring in CTM are also associated with calcium ion imbalance and homeostasis in the human body. However, Finoptine is believed to have the potential for reversing the trend. Aim of this Study: To investigate the peculiarities of the effect of administration of finoptine on calcium ion constituent and urinary hydroxyproline concentrations excretion. Materials and Methods: A total of 15 subjects of between 25-40 years, comprising 8 male psoriatic patients as the experimental group and 7 apparently normal male individuals as control group were investigated. Using Stegnman-Staeder’s quantitative method as modified by Utevskaya and Persky, urinary hydroxyproline was measured and documented. Results: It was found that calcium lactate enhanced the production of hydroxyproline in both psoriatic patients and apparently normal subjects. However, Finoptine is shown to have considerably inhibited the activity of calcium lactate, particularly in psoriatic patients as compared to the normal subjects in the control group, leading to remarkable reduction in hydroxyproline produced by the former. Conclusion: The effect of interaction, which appeared to have occurred between Finoptine and calcium ions, resulting in marked decrease in the stimulation and production of hydroxyproline, may serve as a useful mechanism for chemotherapy and management of psoriasis.